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Intervention All subjects flew from London to Kathmandu overnight.
The time course and altitude ascent profiles for Group 1 and Group 2 are summarised in figures 2 and 3. Expedition day 1 was defined as the day of departure from Kathmandu. The ascent rate was chosen to minimise the incidence of high altitude illness and therefore maximise the number AIMS Lab Xtreme 98 Update subjects able to contribute data at the highest laboratory [ 16 ].
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AIMS Lab Xtreme 98 Update Climbers and Base Camp Team. Laboratories where testing was performed are labeled, intermediate altitudes indicate overnight stops without testing. Group 1 trekkers was divided into 13 smaller groups of a maximum of 16 subjects. Two groups left the UK each week for the duration of the expedition. All Group 1 subjects followed an identical ascent profile arriving at EBC on day 11 figures 2 and 3. This differed from that of group 1 due to the logistical demands of establishing research laboratories and additional testing: On rest days during the ascent to EBC, excursions were strictly limited such that all subjects remained within vertical metres of the laboratory altitude at all times in order to maintain an identical pattern of hypoxic exposure.
United Kingdom; K: Kathmandu m; N: Namche m; P: Pheriche m; E: Everest Base Camp m. Shaded boxes: Testing days Unshaded boxes Group 1: For these investigators, excursions were limited to within vertical metres of the EBC altitude for the duration of the expedition.
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The laboratory staff were not exposed to supplemental oxygen for the duration of the expedition. Climbers were not exposed to any supplemental oxygen until the completion of testing at Camp 2.
Testing was repeated at the end of the expedition immediately prior to departure for all group 2 AIMS Lab Xtreme 98 Update at EBC days 66 to Group 1 subjects were consistently tested either on the day after arrival at any given altitude, or on the following day Day 1 subjects, or Day 2 subjects: For each subject the day of testing was kept constant to control for the effects of continued adaptation at the laboratory altitude. Furthermore, subjects were tested at the same time of day at all laboratories to control for diurnal variations in physiological responses.
At Kathmandu, Namche and Everest Base Camp, group 2 subjects spent the first day after arrival setting up the lab; at Pheriche testing began on the first day after arrival. For group 2, testing was performed over 4 days at Kathmandu, 3 days at Namche, 2 days at Pheriche and 5 days at Everest AIMS Lab Xtreme 98 Update Camp figure 3. For the investigator group, the order of testing was kept constant for the core studies.
To minimise the confounding effects of hypoxic adaptation prior to the study period, all subjects refrained from any form of hypoxic training hypoxic tents etc and did not travel above m for 3 months prior to departure. We developed and used a set of guidelines for the treatment of common altitude AIMS Lab Xtreme 98 Update eg AMS and non-altitude conditions eg acute upper respiratory tract infection, acute gastroenteritissuch that all individuals were treated in a standardized manner. All use of medications was recorded so that individuals receiving medication can be identified and where appropriate will be analyzed as a subgroup.
For example, the use of acetazolamide in the treatment of AMS might have an effect on some of the resting physiological variables and we intend to undertake a subgroup analysis exploring this question. Measurements Core studies Groups 1 and 2 All subjects from both groups were recruited into the 10 core studies unless exclusion criteria were AIMS Lab Xtreme 98 Update.
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